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Published on:September 2021
Indian Journal of Pharmaceutical Education and Research, 2021; 55(3s):xx-xx
Original Article | doi:10.5530/ijper.54.3s.x

HPMC Polymers and Xanthan Gum Assisted Development and Characterization of Stavudine Extended Release Floating Tablets


Authors and affiliation (s):

Purushottam Shridhar Gangane1,*, Tejas Pachpute2, Debarshi Kar Mahapatra3, Nilesh Manoharrao Mahajan1

1Department of Pharmaceutics, Dadasaheb Balpande College of Pharmacy, Nagpur, Maharashtra, INDIA.

2Department of Industrial Pharmacy, I.B.S.S. College of Pharmacy, Malkapur, Buldhana, Maharashtra, INDIA.

3Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Nagpur, Maharashtra, INDIA.

Abstract:

Objectives: Stavudine has a low half-life of 0.8-1.5 hr and therefore needs recurrent administration to sustain stable beneficial drug plasma levels. In order to enhance and preserve the stable drug level of stavudine for round the clock, gastroretentive systems (floating low-density formulations that cause buoyancy on the gastric fluid in the stomach) may prove to be advantageous for releasing the drug content from the matrix tablet reservoirs for several hours. Materials and Methods: The current research endeavors towards formulating the stavudine floating tablet formulations (F1-F9) employing rate modifying polymers such as HPMC K15M, xanthan gum and HPMC K100M using multiple punch tablet compression machine containing 9 mm diameter, round flat-faced punches to form 80 mg tablet with a batch size of 100. The drug-polymer compatibility was investigated through Fourier-Transformed Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC). Results: The stavudine floating tablet formulations were successfully fabricated. The pre-compression characteristics (tapped density, bulk density, Hausner’s ratio, Carr’s index and angle of repose) as well as postcompression characteristics (appearance, hardness, dimension, drug content, friability, swelling index, weight variation, in vitro drug release, in vitro buoyancy, accelerated stability and drug release kinetics for 90 days) of the formulations were comprehensively studied. Conclusion: This research study on stavudine will definitely open several new milestones for anti-retroviral pharmacotherapeutics in the upcoming future perspectives by enhancing the half-life of the drug employing the floating extended-release attributes.

Keywords: Stavudine, Floating, Tablet, Gastroretentive, Xanthan, HPMC.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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