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Published on:May 2021
Indian Journal of Pharmaceutical Education and Research, 2021; 55(2):614-620
Original Article | doi:10.5530/ijper.55.2.101

Rapid Purification of Drug Enantiomers using Supercritical Fluid Chromatographic Method: Ibuprofen as a Model Compound


Authors and affiliation (s):

Hwa Jong Lee2, Jasper Gahm2, Jong Sung Jin3, Yun Gyong Ahn1,*

1Western Seoul Center, Korea Basic Science Institute, University-Industry Cooperation Building, 150 Bugahyeon-ro, Seodaemun-gu, Seoul, REPUBLIC OF KOREA.

2Verdant Technology, University-Industry Cooperation Building, 150 Bugahyeon-ro, Seodaemun-gu, Seoul, REPUBLIC OF KOREA.

3Busan Center, Korea Basic Science Institute, 30 Gwahaksandan 1-ro 60-gil, Gangseo-gu, Busan, REPUBLIC OF KOREA.

Abstract:

Background: The purification of drug enantiomers is an essential technique because pharmacological activity differs depending on individual enantiomers. Nowadays, supercritical fluid technology is utilized for various purposes in the pharmaceutical field. Methodology: In this study, an efficient and streamlined method development strategy for finding an effective analytical method in supercritical fluid chromatography (SFC) is presented in detail for scaling up to preparative scale and achieving enantiomerically pure product, using ibuprofen as a model compound. Results: Through the optimized preparative method presented, the individual (R) enantiomer of the commercial racemate of ibuprofen can be obtained with a recovery yield of 80.0% and an enantiomeric excess of 95.1 and the individual (S) enantiomer can be obtained with a recovery yield of 77.6% with an enantiomeric excess of 99.3, respectively. Conclusion: The use of analytical and preparative SFC systems has advantages over the conventional chromatography systems in terms of separation time, reduced solvent consumption and high productivity for ibuprofen's enantiomeric purification.

Key words: Ibuprofen, Analytical supercritical fluid chromatography (Analytic-SFC), Preparative supercritical fluid chromatography (Prep-SFC), Drug, Enantiomer, Purification.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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