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Published on:May 2021
Indian Journal of Pharmaceutical Education and Research, 2021; 55(2):330-335
Review Article | doi:10.5530/ijper.55.2.70

An Overview of Dual Targeting Nanostructured Lipid Carriers for the Treatment of Ovarian Cancer

Authors and affiliation (s):

Praharsh Kumar Mandadhi Rajendra1, Natarajan Jawahar1,*, Rajeshkumar Raman2, Hagalavadi Nanjappa Shivakumar3, Anjali Puthusserikkunnu Balan1

1Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Nilgiris, Tamil Nadu, INDIA.

2Department of Pharmaceutical Biotechnology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Nilgiris, Tamil Nadu, INDIA.

3Department of Pharmaceutics, KLE College of Pharmacy, Bengaluru, Karnataka, INDIA.


Purpose: To summarize main findings from research on oral delivery of Nanostructured lipid carriers targeting ovarian cancer. Methods: A narrative review of all the relevant papers known to author was conducted. Results: Ovarian cancer is one of the most common gynaecologic cancer, the frontline treatments for which are surgical approach followed by radiotherapy or chemotherapy. Chemotherapy has its own limitations; consequently, there is a need to develop a targeted drug delivery system with high efficacy. Preclinical evidence suggests that combination therapies are likely to be effective in ovarian cancer. However, from clinical reports, it is evident that chemotherapeutic drugs have lower therapeutic value for the treatment of ovarian cancer. We propose that these limitations can be overcome by a novel formulation consisting of nanostructured lipid carriers. Recent pharmacological research has successfully potentiated the effects of combination therapy in acute animal preparations by inhibiting proteins that are involved in different physiological pathways of cancer cells. Conclusion: We have reviewed the scope of nanostructured lipid carriers concerning chemotherapy of ovarian cancer. The advantages of oral administration of these lipid carriers are discussed. Also, the various nano-lipid formulations and combination therapies reported along with their therapeutic outcomes have been reviewed. In light of this, nanostructured lipid carriers containing two different active ingredients for oral administration could be a potential approach for the effective treatment of ovarian cancer.

Key words: Ovarian cancer, Nanostructured lipid carriers, Dual targeting, Chemotherapy, Oral delivery.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
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Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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