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Published on:March 2021
Indian Journal of Pharmaceutical Education and Research, 2021; 55(1s):s1-s10
Review Article | doi:10.5530/ijper.55.1s.33

Nano-transethosomes: A Novel Tool for Drug Delivery through Skin

Authors and affiliation (s):

Kajal Jagdish Bajaj, Bhagyashri Surendra Parab, Supriya Shrihari Shidhaye*

Department of Pharmaceutics, Vivekanand Education Society’s College of Pharmacy, Mumbai, Maharashtra, INDIA.


Transdermal drug delivery has become a popular tool from last few years. It overcomes drawbacks which are encountered with the oral route. Though very few routes are as attractive as transdermal route, transport of drug through the skin is challenging. In order to overcome the challenges, researchers have found a system in which the drug is encapsulated into the vesicle and these vesicles can penetrate deeper into the skin to hit the target site. Hence, better skin penetration of bioactive agents can be achieved. Vesicular systems like liposomes, niosomes, ethosomes and Transferosomes tend to remain accumulated in the skin layers. Since Transethosomes have small particle size and can easily alter the shape of vesicle as compared with other vesicular systems; it can penetrate through the layers of skin. Hence, the drug encapsulated into Transethosomes can easily reach the target site. Transethosomes consist of ethanol, phospholipids along with an edge activator. Ethanol and edge activator help to enhance skin permeation of Transethosomes. Since it is a non-invasive technique, it improves patient compliance. It also increases drug entrapment efficiency. These vesicles can accommodate different variety of drugs such as anticancer, corticosteroids, proteins and peptides, analgesics.

Key words: Transdermal delivery system, Transethosomes, Vesicles, Skin permeation, Non-invasive, Entrapment efficiency.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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