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Published on:February 2021
Indian Journal of Pharmaceutical Education and Research, 2021; 55(1):240-248
Original Article | doi:10.5530/ijper.55.1.27

Tribulus terrestris Saponins Improve Ovarian Ischemia-reperfusion Injury in Female Rats: Modulation of Vascular Endothelial Growth Factor-A and Hemeoxygenase-1


Authors and affiliation (s):

Asmaa Mohamed Abdel-Aziz1,*, Hanaa Hassanein Mohammed2, Osama Abdelazem3, Rasha Fouad Ahmed4, Yasmine F. Ibrahim1

1Department of Pharmacology, Faculty of Medicine, Minia University, Minia, EGYPT.

2Department of Histology and Cell Biology, Faculty of Medicine, Minia University, Minia, EGYPT.

3Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Assuit, EGYPT.

4Department of Medical Biochemistry, Faculty of Medicine, Minia University, Minia University, Minia, EGYPT.

Abstract:

Aim/Background: Ovarian I/R is a popular gynecological emergency, complicating ovarian torsion. TTS, reported to have many therapeutic effects along with being an antioxidant, anti- inflammatory and anti-apoptotic agent. The aim of this study was to estimate the probable protective role of Tribulus terrestris Saponin (TTS) in recovering the damaging effects of ischemia-reperfusion (I/R) in the female rats' ovarian tissue. Materials and Methods: TTS was treated to female rats in presence or absence of ovarian I/R. Results: I/R caused ovarian damage, represented by deformity in normal ovarian histological structure, with a significant oxidative and nitrosative stress along with obvious inflammatory damage. Pretreatment with TTS significantly reversed the I/R induced ovarian toxic effects. TTS may have valuable ovarian protective effects against ovarian I/R injury. Conclusion: TTS protection is given via antioxidant, anti-nitrosative, anti-inflammatory and anti-apoptotic mechanisms with advancement of vascular angiogenesis and pituitary-gonadal axis up regulation.

Key words: Apoptosis, Angiogenesis, Immunohistochemical study, Ovarian ischemia/ reperfusion, Tribulus terrestris saponin.

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