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Published on:February 2021
Indian Journal of Pharmaceutical Education and Research, 2021; 55(1):126-135
Original Article | doi:10.5530/ijper.55.1.15

Protective Effect of Natrium Diethyldithiocarbamate Trihydrate (NDDCT) on Lead Induced Neurodegeneration in Rats


Authors and affiliation (s):

Sudhir Kumar1,2, Harikesh Maurya1,3, Sandeep4, Saikat Sen5, Raja Chakraborty6,*

1Department of Pharmacology, Hygia Institute of Pharmaceutical Education and Research, Lucknow, Uttar Pradesh, INDIA.

2Department of Pharmacology, JS Singh Institute of Pharmacy, Dhondhi-Parasarai, Uttar Pradesh, INDIA.

3Department of Pharmacology, MGB Rajat College of Pharmacy and Management, Ambedkarnagar, Uttar Pradesh, INDIA.

4Department of Pharmacognosy Praduman Singh Shikshan Prashikshan Sansthan Pharmacy College, Basti, Uttar Pradesh, INDIA.

5Faculty of Pharmaceutical Science, Assam Down Town University, Guwahati, Assam, INDIA.

6Department of Pharmaceutical Chemistry, NEF College of Pharmacy, Guwahati, Assam, INDIA.

Abstract:

Aim: Lead is a powerful metal which induced neurotoxicity through the degradation of neurons in the body. Various neuronal changes have shown correlation with the generation of free radicals and oxidative stress. The present study was carried out to evaluate the neuroprotective activity of Natrium diethyl dithiocarbamate trihydrate (NDDCT) on lead induced neurodegeneration in rat’s model. Methods: We have evaluated the neuroprotective activity of NDDCT using Morris Water maze, Elevated plus maze, Photoactometer and Hebb’s William maze models and also evaluated different biochemical parameters. Neurodegeneration was induced by administering lead acetate (1 mg/kg/day) for 35 days. Test drug NDDCT (5 mg/kg and 10 mg/kg) and standard drug donepezil were also administered concurrently in test and standard drug treated group. Results: NDDCT found to improve escape latency time (in Morris Water Maze), transfer latency time (in Elevated plus Maze), time to reach reward chamber (Hebb William’s Maze) and locomotor activity. The neuroprotective activity of NDDCT was confirmed by evaluation of in vivo antioxidant and estimation of other biochemical parameters. NDDCT found to improve the level of reduced glutathione, catalase, superoxide dismutase, sodium nitrate and reduced the level of serum lead, TNF-α, nitric oxide, acetylcholinesterase enzyme in the test group when compared with the disease control group. Histopathological evaluation of the brain also confirms the protective effect of NDDCT. Conclusion: These results suggest that NDDCT can be used as a preventive drug against lead-induced neurodegeneration, cholinergic dysfunctions and oxidative stress.

Key words: Natrium diethyldithiocarbamate trihydrate (NDDCT), Neuroprotective, Biomarkers, Physical activity, Neurodegeneration, Cholinergic dysfunction.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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