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Published on:February 2021
Indian Journal of Pharmaceutical Education and Research, 2021; 55(1):146-152
Original Article | doi:10.5530/ijper.55.1.1

Disposal of Uranium and Thorium Entering the Human Digestive System before Reaching the Blood by Adsorption on Simethicone and Forming a Non-absorbable Compound: A Full in vitro Analysis


Authors and affiliation (s):

Hamed Ibrahim Mira1, Nashat Mohamed Alanwar Abdalaty2,*

1Professor of Geochemistry and Chairman of Nuclear Material Authority, Nuclear Materials Authority, Maadi, Cairo, EGYPT.

2Department of Medicinal and Radiation Research, Nuclear Materials Authority, Maadi, Cairo, EGYPT.

Abstract:

Introduction: This method was applied to form a non-absorbable complex with uranium and thorium swallowed with contaminated dust or other sources to get rid of them before absorption into the blood and discarded outside the body. A non-GIT absorbable simethicone was used in this method for the adsorption of uranium (VI) and thorium (IV) from a solution similar to the gastrointestinal tract pH medium. Materials and Methods: Accurately measured 9 mg of pure standard uranyl nitrate and simethicone emulsion in concentration range (100-300 mg) at 37±1°C for 20 min in pH ranges like the medium of the stomach and intestine then take the supernatant after centrifugation to make sure of decreasing of the concentration of uranium and thorium ions by ICP Mass Spectroscopy (ICP-MS). Results and Discussion: The data recorded for different total uranium and thorium concentrations reveal convergent behavior. Increasing simethicone concentration inside the safe dose shifts the sorption of uranium and thorium to 100 % of the total concentration, calculated t and F values were compared with the reference method and the proposed method was equally precise and accurate. Conclusion: The data indicate that the method can successfully be applied for the complete adsorption of uranium and thorium on simethicone from GIT before reaching the blood.

Key words: Simethicone, Uranium, Thorium, Protection, Non-absorbable complex.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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