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Published on:August 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(3):826-834
Original Article | doi:10.5530/ijper.54.3.135

Fabrication of Poly (sebacic acid-co-ricinoleic-ester anhydride) with β-cyclodextrin-loaded doxorubicin Implants and in vitro characterization


Authors and affiliation (s):

Nagaraja Sreeharsha1,9,*, Jagadeesh G Hiremath2, Bandar E Al-Dhubiab1, Girish Meravanige3, Ranjith Kumar Karnati4, Mahesh Attimarad1, Anroop B Nair1, Katharigatta N Venugopal1,10, Mohamed A Morsy1,8, Shinu Pottathil5, Saleemmulla Khan6, Nagashekhara Molugulu7

1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.

2Department of Pharmaceutics, PA College of Pharmacy, Mangalore, Karnataka, INDIA.

3Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.

4Department of Chemistry, College of Science, King Faisal University, Al-Ahsa, SAUDI ARABIA.

5Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.

6Department of Pharmacognosy, PA College of Pharmacy, Mangalore, Karnataka, INDIA.

7School of Pharmacy, Monash University, Jalan Lagoon Selatan, Bandar Sunway, Selangor, MALAYSIA.

8Department of Pharmacology, Faculty of Medicine, Minia University, El-Minia 61511, EGYPT.

9Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, INDIA.

10Department of Biotechnology and Food Technology, Durban University of Technology, Durban, SOUTH AFRICA.

Abstract:

Background: Doxorubicin is an excellent molecule for the formation of biodegradable implants using the poly (sebacic acid-co-ricinoleic-ester anhydride) 70:30 w/w (poly[SARA] 70:30 w/w PSRA 7/3) polymer. Methods: The cylindrical implants were successfully produced by means of hot melt extrusion. We used differential scanning calorimetric (DSC) and X-ray diffraction (XRD) methods to identify the melting state and crystal type of blank and drug-loaded implants. A study was conducted on PSRA 7/3 w/w blank and drug-loaded implants for in vitro hydrolytic degradation. The drug present in the remaining sample was estimated. Results: The hydrolytic degradation rate of the 10% w/w (F2)-loaded implant was relatively low when compared with the 20% w/w (F3) implant. Discussion: In vitro drug release studies illustrated that the drug-release rate was faster in association with increasing amounts of doxorubicin in the implant.

Key words: Poly(sebacic acid-co-ricinoleic-ester anhydride) 70:30 w/w, Doxorubicin, β-cyclodextrin, Cylinder, Biodegradable polymer, in vitro.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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