Home | Articles
Published on:Jul 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(3):206-210
Original Article | doi:NILL

Synthesis and Pharmacological Evaluation of New 4-Aryl-3,4,5,6,7,8- hexahydroquinazolin-2(1H)-thiones

Authors and affiliation (s):

C.M Aslak, B. Jayalakshmi*, A.Balasubramaniam and N. Senthilkumar.
Department of pharmaceutical chemistry, JKK Munirajah Medical Research Foundation, College of Pharmacy, Komarapalayam - 638 183,Tamilnadu, India


New 4-aryl substituted quinazolin-2-thiones were synthesized and confirmed by spectral studies like IR and NMR. Then screened for antimicrobial, analgesic, anti-inflammatory and CNS depressant activities. All the derivatives were showing the pharmacological activity mainly due to the presence of basic nucleus, quinazolin-2-thione and was modified with various substituents at 4th position with different aryl substituents. Among all the substituents, the halogen substituted compounds are comparatively more active.

Keywords: Quinazolinones, cyclohexanone, chalcones, Aldol condensation, cylization.



Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).


Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

User login

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs