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Published on:September 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(4):724-732
Original Article | doi:10.5530/ijper.53.4.137

Formulation Development and Evaluation of Gastro Retentive Bio Adhesive Drug Delivery System for Moxifloxacin. HCl


Authors and affiliation (s):

Raghavendra Kumar Gunda1,*, Arumugam Vijayalakshmi2

1School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, INDIA.

2Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, INDIA.

Abstract:

Objective: The purpose of present research work is to develop gastro retentive formulation for Moxifloxacin using various drug release modifiers. Moxifloxacin, novel synthetic fluoro quinolone, antibacterial agent. Methods: SR granules were prepared by gastro retentive tablets of Moxifloxacin. HCl were prepared using variable amounts of HPMCK100M, Lannea coromandelica gum (LCG) by moist granulation technique. Totally 10 SR granule formulations were prepared and subjected to precompression analysis and drug release profiles. Based on the results screening of concentrations for polymers and are used for Tablet formulations. Six tablet formulations were designed and are evaluated for various pharmacopoeial tests. Drug release profiles of formulation trails subjected to kinetic modeling. a,b,r were determined. Results: The results reveals that retention time decreases with decreased viscosity of polymer. F16 prepared with LCG was found to have highest swelling property. High bioadhesive strength of the formulation is likely to increase its GI residence time. Lannea coromandelica gum powder needs to explored as a sustain release material at commercial scale.

Key words: Moxifloxacin. HCl, Gastroretentive, Bio adhesion, HPMCK100M, Lannea coromandelica gum, Swelling Study.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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