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Published on:July 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(3):366-375
Review Article | doi:10.5530/ijper.53.3.70

Recent Advancement in in-vivo and in-vitro Toxicity Studies for Ayurvedic Formulation


Authors and affiliation (s):

Ruchi Bhattacharya1, Manisha Sahu1, Vikash Sharma1, Shiv Shankar Shukla2, Ravindra Kumar Pandey3,*

1Department of Pharmacology, Columbia Institute of Pharmacy, Raipur, Chhattisgarh, INDIA.

2Department of Pharmaceutical Analysis and Quality Assurance, Columbia Institute of Pharmacy, Raipur, Chhattisgarh, INDIA.

3Department of Pharmacognosy, Columbia Institute of Pharmacy, Raipur, Chhattisgarh, INDIA.

Abstract:

Aim: Ayurvedic formulation consists of natural substance. Many of Ayurvedic formulation consist of heavy metals and some species are poisonous in nature. So it is necessary to determine the toxicity of Ayurvedic formulation. Background: Toxicology is a science that involves the study of the adverse effect of the substance on living organism. The toxicity of the substance can be observed by: a) in vivo (using the whole animal), b) in vitro (Testing on isolated cell or tissue). In vivo toxicity study involves acute toxicity, sub-acute toxicity, sub-chronic toxicity and chronic toxicity studies. In vitro toxicity testing of substance involves model such as model for cytotoxicity, specific toxicity, genotoxicity and toxicokinetic. The challenges regarding in vivo and in vitro toxicity study and recent development in the toxicity studies are discussed briefly. Conclusion: This review mainly focus on the various methods and model used for in vivo and in vitro toxicity testing of substance and provides information about the toxicity study which will be useful for the researchers who are working in the field of toxicology as well encourage researchers to work on various areas of research for the development and enhancement in acceptance of Ayurveda.

Key words: Ayurvedic formulation, in vivo toxicity, in vitro toxicity, Specific toxicity, Toxicokinetic, Toxicology.

 

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IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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