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Published on:July 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(3):457-467
Original Article | doi:10.5530/ijper.53.3.78

Liquisolid Compact Tablet of Candesartan Cilexetil with Enhanced Solubility using Neusilin US2, Aerosil 200 and Transcutol HP


Authors and affiliation (s):

Pallavi Argade, Vinita Chandrakant Patole, Ashlesha Pravin Pandit*

Department of Pharmaceutics, JSPM Rajarshi Shahu College of Pharmacy and Research, Tathawade, Pune, Maharashtra, INDIA.

Abstract:

Objective: An attempt was made to enhance solubility, dissolution and intestinal permeability of drug candesartan cilexetil by liquisolid technology. Methods: Liquisolid tablet was formulated using non-volatile solvent Transcutol HP, carrier material Neusilin US2 and coating material Aerosil 200. Appropriate quantities of excipients were calculated with the help of mathematical model to get liquisolid powder. A 32 full-factorial design was used further to optimize liquisolid powder. Results: DSC, XRD and SEM studies revealed absence of crystalline nature of drug in liquisolid powder. Liquisolid powder was further compressed into tablet and subjected to various evaluation tests such as in-vitro drug release and ex-vivo intestinal permeation study. Conclusion: Liquisolid technology was found to be promising due to enhance solubility, dissolution and permeation of candesartan cilexetil by 19.75, 3.09 and 2.4-fold, respectively.

Key words: Candesartan cilexetil, Transcutol HP, Neusilin, Aerosil 200, Liquisolid technology, ex-vivo study.

 

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IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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