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Published on:April 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(2s):s104-s111
Original Article | doi:10.5530/ijper.53.2s.54

Medhya Rasayana Restores Memory Function against Doxorubicin-induced Cognitive Decline: Possibly by its Neuroprotective Effect


Authors and affiliation (s):

Karthik Gourishetti1, Sawan Ghetia1, Ligin Jacob1, Sanchari Basu Mallik1, Pawan Ganesh Nayak1, Anoop Kishore1, Krishnadas Nandakumar1,*, Sulaiman Mohammed Alnaseer2, Shalam Mohamed Hussain2

1Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA.

2Department of Pharmacology and Toxicology, Unaizah College of Pharmacy, Qassim University, Unaizah, Kingdom of SAUDI ARABIA.

Abstract:

Background: Medhya Rasayana (MR) is an ayurvedic formulation used to rejuvenate the intellectual functions. It was shown to improve the cognitive function in rats. Hence, the present study was designed to study the neuroprotective effect of MR against Doxorubicin (DOX)-induced cognitive deficits which usually occurs in long-term breast cancer survivors. Methods: The neuroprotective effect of MR was studied in-vitro using IMR-32 cell lines against DOX-induced toxicity while the protective effect of MR against DOX-induced cognitive dysfunction was evaluated in Novel object recognition task (NORT) assay in rats. Results: In IMR-32 cell line, DOX (100 nM) treatment reduced the cell viability and arrested the cell cycle at G2/M phase. Pre-treatment with MR significantly prevented the DOX-induced cytotoxicity and reduced the G2/M phase arrest indicating that MR exhibits protection against DOX-induced toxicity. In NORT, DOX treatment significantly decreased the Recognition and discriminative indices (RI and DI) indicating DOX impairs episodic memory. Treatment with MR (1.26 and 1.52 g/ kg) significantly protected against DOX-induced cognitive dysfunctions. DOX treatment also increased the brain oxidative stress and produced hepato, cardio, nephrotoxicity and myelosuppression. MR treatment ameliorated the DOX-induced toxicity. Conclusion: These results showed that MR pre-treatment could protect against post chemotherapyinduced cognitive dysfunction along with an overall reduction in chemotherapy-induced toxicity.

Key word: Doxorubicin, Medhya Rasayana, Chemobrain, Cognitive dysfunction, Chemotherapy, Novel object recognition task.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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