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Published on:April 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(2s):s129-s134
Original Article | doi:10.5530/ijper.53.2s.57

Synthesis and Characterization of Novel N-Benzylbenzimidazole Linked Pyrimidine Derivatives as Anticancer Agents


Authors and affiliation (s):

Gopal Krishna Padhy1,2, Jagadeesh Panda3, Ajaya Kumar Behera1,*

1Organic Synthesis Laboratory, School of Chemistry, Sambalpur University, Jyoti Vihar, Burla, Odisha, INDIA.

2Department of Pharmaceutical Chemistry, Maharajah's College of Pharmacy, Phool Baugh, Vizianagaram, Andhra Pradesh, INDIA.

3Department of Pharmaceutical Chemistry, Raghu College of Pharmacy, Dakamarri, Visakhapatnam, Andhra Pradesh, INDIA.

Abstract:

Background: Emergence of resistance to accessible anticancer drugs became a threat to human lives in the recent time. To address this issue, discovery of novel anticancer agents becomes very essential. Benzimidazoles and pyrimidines have been reported to possess potent anticancer activity. Materials and Methods: A hybrid approach has been used, in which core structure of potentially active N-benzyl benzimidazole and pyrimidine derivatives are brought together in to a single molecule. The desired compounds were prepared by the condensation of N-benzyl benzimidazole chalcones with guanidine hydrochloride. The synthesized compounds were characterized using spectral studies (IR, 1H, 13C-NMR techniques and mass spectrometry). All the compounds were screened for their anticancer activity against human breast cancer cell line MDA-MB-231. Results: The spectral data’s are in well agreement with the synthesized compounds 5a-e. Compounds 5b (GI50 = 39.6 μM) and 5a (GI50=84.0 μM) exhibited significant anticancer activity. Conclusion: Owing to the anticancer activity, compound 5b can be used as lead structure in the development of yet more potent anticancer agents.

Key words: Chalcone, Benzimidazole, Pyrimidine, Anticancer activity, SRB assay.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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