This study was examined a photostability of Karvileks (Zdravlje-Actavis, Serbia), packed in the different primary packs. For these examination, the experimental design with 3 independent variables: wavelength of radiation (X ), duration of radiation (X ) and type of packs (X ) was applied. After irradiation of Karvileks, the 1 2 3 content of carvedilol and its impurities A, B and C was taken as a response (Y , Y , Y Y ). The obtained mathematical equations can be used for determination of 1 2 3, 4 carvedilol and its impurities content in any case. Tablets were packed in an opaque plastic container, as well as in red blister. The content of carvedilol was determined using a stability-indicating RP-HPLC method. Read more...
Keywords: experimental, design, photostability, Karvileks.