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Published on:Jul 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(3):275-282
Original Article | doi:NILL

Application of the experimental design method to photostability studies of Karvileks tablet

Authors and affiliation (s):

Ivana Savic1*, Valentina Marinkovc2, Ivan Savic1, Predrag Sibinovic3 and Nebojsa Cekic4

1Faculty of Technology, Univerzity of Nis, Bulevar oslobodjenja 124, Leskovac, Serbia

2Faculty of Pharmacy, Vojvode Stepe 450, Belgrade, Serbia

3Pharmaceutical and Chemical Industry - Zdravlje Actavis, Vlajkova 199, Leskovac, Serbia.

4 DCP Hemigal, Leskovac, Serbia.


This study was examined a photostability of Karvileks (Zdravlje-Actavis, Serbia), packed in the different primary packs. For these examination, the experimental design with 3 independent variables: wavelength of radiation (X ), duration of radiation (X ) and type of packs (X ) was applied. After irradiation of Karvileks, the 1 2 3 content of carvedilol and its impurities A, B and C was taken as a response (Y , Y , Y Y ). The obtained mathematical equations can be used for determination of 1 2 3, 4 carvedilol and its impurities content in any case. Tablets were packed in an opaque plastic container, as well as in red blister. The content of carvedilol was determined using a stability-indicating RP-HPLC method. Read more...

Keywords: experimental, design, photostability, Karvileks.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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