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Published on:January 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(1):8-20
Review Article | doi:10.5530/ijper.53.1.3

Chemistry and Pharmacology of Flavonoids- A Review


Authors and affiliation (s):

A. C. Rana*, Bhawna Gulliya

Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana- 136119, INDIA.

Abstract:

Several modern and most of the traditional drugs have been developed from natural sources. Flavonoids or bioflavonoids, most ubiquitous polyphenolic compounds, are secondary metabolites of plants and fungal origin. Apart from their biological functions in plants (protection against herbivores, ultraviolet radiation and pathogens), they perform myriads of pharmacological activities in humans as well. Though flavonoids are not acknowledged as nutrients still their intake on regular basis is considered fruitful for human health. Flavonoids are biosynthesized through phenylpropanoid pathway and contain a C6-C3-C6 carbon framework. The present review has reviewed the chemistry, structure and classification of flavonoids. Additionally, their occurrence and chemical properties have also been explored. Moreover, we discuss about the different mechanisms through which flavonoids act like direct radical scavenging, leukocyte immobilization and interaction with different enzymes. Flavonoids own a number of pharmacological activities such as anti-parkinson, anti-ulcer, spasmolytic, anti-depressant, anti-bacterial, anti-hypertensive, anti-diabetic, anti-inflammatory and anti-cancer. This review intent to give healthy information for formation of new flavonoid based pharmaceutical formulation to act against various diseases.

Key words: Flavonoids, Polyphenolic compound, Pharmacological activity, Mechanism, Biosynthesis.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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