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Published on:August 2018
Indian Journal of Pharmaceutical Education and Research, 2018; 52(4s):s16-s22
Original Article | doi:10.5530/ijper.52.4s.71

Development of Fluconazole Suppositories for the Treatment of Candida Infection of Genitourinary Tract


Authors and affiliation (s):

R. Saketh Reddy1, Lalit Kumar1*, Chinna Raja Pydi1, M. Sreenivasa Reddy1, Ruchi Verma2

1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Madhav Nagar, Manipal 576 104, Karnataka, INDIA.

2Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Madhav Nagar, Manipal 576 104, Karnataka, INDIA.

Abstract:

Background: Vulvovaginal candidiasis is a communal problem in virtually all the women which is caused by Candida albicans. Objective: Aim of the present study was to prepare and characterize vaginal suppositories of fluconazole for the treatment of vulvovaginal candidiasis. Methods: Fluconazole suppositories were prepared using water soluble and fatty bases. Bases and their proportions used were selected in such a way that they have flexibility in storage conditions unlike conventional suppositories. Suppositories were prepared and examined for physical characteristics and in vitro release studies. Results: Present study showed ultimate results with respect to the physical characteristics of suppositories and in vitro drug release studies. In vitro drug release from the prepared suppositories was in the following order FVS 3 (100.00 ± 3.7% in 1.0 h) > FVS 1 (86.29 ± 4.9% in 12.0 h) > FVS 2 (80.47 ± 2.4% in 12.0 h) > FVS 5 (22.51 ± 0.42% in 24.0 h) > FVS 4 (18.09 ± 1.31% in 24.0 h). These drug release results are supported by the disintegration time of suppositories. Lesser the disintegration time faster the drug release. Conclusion: Study concludes that it may be fruitful to explore the in vivo activities of suppositories prepared with the combination of agar and HPMC as it showed around 80% drug release over 12.0 h. Represented combination may also be more effective for the treatment of vulvovaginal candidiasis.

Key words: Vulvovaginal candidiasis, Candida albicans, Fluconazole, Fluconazole suppositories, Vaginal suppositories, Vaginal infection, Agar, Hydroxypropyl methylcellulose, Glycerol-gelatin, Cocoa butter, Bees wax.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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