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Published on:June 2018
Indian Journal of Pharmaceutical Education and Research, 2018; 52(3):416-425
Original Article | doi:10.5530/ijper.52.3.48

Antiparasitic Efficacy of Artemisia ludoviciana Nutt. (Asteraceae) Essential Oil for Acanthamoeba castellanii, Leishmania infantum and Trichomonas vaginalis


Authors and affiliation (s):

Ayşe Baldemir1*, Ülkü Karaman2, Selen İlgün1, Gamze Kaçmaz2, Betül Demirci3

1Erciyes University, Faculty of Pharmacy, Department of Pharmaceutical Botany, Kayseri, TURKEY.

2Ordu University, Faculty of Medicine, Department of Medical Parasitology, Ordu, TURKEY.

3Anadolu University, Faculty of Pharmacy, Department of Pharmacognosy, Eskişehir, TURKEY.

Abstract:

Background: Artemisia ludoviciana Nutt. (Asteraceae) is an aromatic, herbaceous, perennial plant and known commonly name as “White Sage”, “Black Sage”, “Prairie Sage” or “Cudweed Sagewort”. It is traditionally used as an antispasmodic, anthelminthic, antidiarrhoeal, stomachic, hepatic colic, appetizer, and regulator of menstruation, antimalaric and antiparasitic efficiancy. Objective: The essential oil composition of the flowering herb of A. ludoviciana (AL) was investigated and for the first time, the oil was screened for antiparasitic activity. Methods: The chemical composition of the hydrodistilled essential oil (EO) obtained from the herb with flowered of A. ludoviciana was analyzed by Gas Chromatography–Flame Ionization Detector (GC-FID) and Gas Chromatography–Mass Spectrometry (GC-MS). Results and Discussion: The outcomes showed that the major components of oil were camphor (40.6%), 1,8-cineole (25.5%) and camphene (4.7%), among 45 identified compounds, comprising 98.5 of the total oil. In addition, the oil was tested against Acanthamoeba castellanii, Leishmania infantum and Trichomonas vaginalis. Conclusion: In this study, it is first demonstrated that A. ludoviciana essential oil (AL-EO) is effective against three important parasites.

Key words: Artemisia ludoviciana, Camphor, 1,8-Cineole, Camphene, Antiparasitic effect, GC-FID, GC/MS.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs