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Published on:JANUARY 2018
Indian Journal of Pharmaceutical Education and Research, 2018; 52(1):54-61
Original Article | doi:10.5530/ijper.52.1.6

Pharmaceutical Formulation and Biochemical Evaluation of Atorvastatin Transdermal Patches


Authors and affiliation (s):

Tamer M. Shehata1,2, Omar M.M. Mohafez1,3, Hamza N. Hanieh4

1College of Clinical Pharmacy, King Faisal University, Ahsaa, SAUDI ARABIA.

2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, EGYPT.

3Department of Biochemistry, Faculty of Pharmacy, Al-Azhar, Assiut University, EGYPT.

4Department of Biological Sciences, Faculty of Science, King Faisal University, Ahsaa, SAUDI ARABIA.

Abstract:

Atorvastatin is a lipid lowering agent and widely used to treat hypercholestermia. However following oral administration, the bioavailability of the drug is only 12% due to extensive first pass metabolism. The aim of the current research was to formulate ATO- transdermal patches utilizing various polymers combinations. Hydroxypropyl methylcellulose with either eudragit RS100 or Polyvinylpyrrolidone were mixed in different ratios, in presence of polyethylene glycol 400 as plasticizer. The patches were prepared by solvent evaporation method. Physicomechanical parameters such as, drug content, patch thickness, tensile strength, moisture loss and moisture gained were evaluated. Additionally drug excipient compatibility was assessed by FTIR and DSC. In vitro drug release was measured in phosphate buffer pH 7.4 at 37°C. Finally, biochemical evaluation of the best formulae was evaluated on hyperlipidemic-induced rats. The results indicated that, Hydroxypropyl methylcellulose: Polyvinylpyrrolidone in a ratio of 3:1 showed the most appropriate physicomechanical characters with confirmed physical and chemical drug-polymer compatibility. In addition, the in-vitro experiment showed enhanced atorvastatin release over 24hr. The pharmacological evaluation of F2 formula indicated a significant hypolibedimic effect compared to orally administered atorvastatin. The results revealed that, atorvastatin transdermal patch could be considered as promising drug delivery system for hyperlipidemic patients.

Key words: Atorvastatin, Patches, Polymers, FTIR, DSC, Hyperlipidemia.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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