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Published on:December 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(4s):s522-s530
Review Article | doi:10.5530/ijper.51.4s.79

Past and Future of in-vitro and in-vivo Animal Models for Diabetes: A Review


Authors and affiliation (s):

Hemlata Dewangan2, Raj Kumar Tiwari1, Vikas Sharma1, Shiv Shankar Shukla1, Trilochan Satapathy1, Ravindra Pandey1*

1Department of Herbal Drug Development, Columbia Institute of Pharmacy, Raipur, Chattisgarh, INDIA.

2Post Graduate, Research Scholar, Columbia Institute of Pharmacy, Raipur, Chattisgarh, INDIA. 

Abstract:

Diabetes mellitus is classified into two major types, Type 1 (Insulin Dependent Diabetes Mellitus) and Type 2 (Non-Insulin Dependent Diabetes Mellitus). In world about 90% of diabetes patients are of Type 2 diabetes. There are various in-vivo and in-vitro methods available for the screening of new antidiabetic drugs. In-vivo models mainly uses chemical such as streptozotocin, alloxan etc. for the induction of diabetes where as in-vitro techniques, directly show its effect on cells which are responsible for induction of diabetes in human. In vitro techniques provide more accurate data and possible mechanism which are involved in diabetes disease. Now, a day’s newer techniques such as diabetes induction with the help of viruses had been also introduced which are proving to be good tool in evaluation of antidiabetic drugs. This review could prove to be a good tool for the researchers who seek to do research on diabetes as it is providing vast resource about diabetic model under single umbrella.

Key words: Diabetes, in vivo, in vitro, STZ, Alloxan.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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