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Published on:20 sep 2013
Indian Journal Of Pharmaceutical Education & Research, 2013; 47(2):199-205
Research Article | doi:

Design and Development of Melt Sonocrystallization Technique for Carbamazepine


Authors and affiliation (s):

Vikram Deshmukh*1, Tejeswini Deshmukh2, Madhuri Deshmukh3 and Pankaj Jadhav1
1M.S.S.College of Pharmacy Medha, Satara, Maharashtra, India.
2Arvind Gavali College of Pharmacy, Jaitapur, Satara, Maharashtra, India.
3 R.D.College of Pharmacy, Bhor, Pune, Maharashtra, India

Abstract:

The aim behind the development of particle design techniques is to alter the physicochemical, micromeritics and biopharmaceutical properties of the drug. Melt sonocrystallization a novel technique of particle engineering to enhance dissolution of hydrophobic and other drugs having solubility problem and to study its effect on crystal properties of drug. Melt sonocrystallization process was developed for the drug carbamazepine in which carbamazepine melt was poured in deionized water maintained at 60°C and simultaneously subjected to ultrasonic energy. The agglomerates obtained after solidification of dispersed droplets were separated by filtration and dried at room temperature. The agglomerates obtained were evaluated by using percent drug content, Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), X-Ray Powder Diffractometry (XRPD) and In Vitro drug release. The agglomerates with more or less porous surface were obtained. The agglomerates comprised of crystals having different crystal habits as needles, plates, and some hollow tubes. Saturation solubility increased with the treatment of ultrasonic energy. SEM and XRPD confirmed crystal habit changes. Carbamazepine agglomerates has yielded, comprising of irregular in shape having rough surface with pores developed by MSC technique. The MSC Carbamazepine agglomerate has shown porous surface and cracks in the crystals of the drug. Saturation solubility increased with the treatment of ultrasonic energy. The entire agglomerates look somewhat spongy in nature and have shown significantly higher specific surface area and thereby increase in saturated solubility.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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