Formulation of an Emulgel Containing Strawberry Fruit Extract and in-vivo Evaluation for Different Skin Parameter

Abstract:

Introduction: It has been indicated from previous research that strawberry consumption may be beneficial to improve skin appearance and its extract has antioxidant and antiinflammatory effects. Objective: The aim of present study was to fabricate an emulgel containing extract of strawberry (4%) and in-vivo evaluation on different skin parameters versus its base taken as control. Methods: Strawberry fruit extract, which was obtained by concentrating methanolic extract of strawberry fruit, was entrapped in the inner oily phase of (o/w) emulsion and then incorporated this emulsion into gel to develop emulgel. Both base (without extract) and active formulation were stored at different accelerated conditions for a period of six weeks to predict their stability. For in-vivo evaluation, both formulations were applied to the cheeks of healthy female human volunteers (n=13) for twelve weeks and various skin parameters were evaluated to measure any effect on skin produced by base and active formulations.The instrumental measurements were carried out with controlled temperature (18-20.6C°) and relative humidity (55- 65%). Results: Skin melanin, erythema and sebum showed a significant (decrease by active formulation. A significant (increase in skin moisture content was found by active formulation. Conclusion: Strawberry emulgel can be used to improve texture of skin and enhance whiting effect without causing any skin irritation.

Key words: Strawberry, Emulgel, Stability, Melanin, Sebum, Erythema.