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Published on:July 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(4):603-612
Original Article | doi:10.5530/ijper.51.4.90

An Evaluation of Antioxidant Potential of Flavonoid Eriodictyol in Isoproterenol-Induced Myocardial Infarction in Rats


Authors and affiliation (s):

Preethi Hariharan, Mariyappan Palani, Manju Vaiyapuri*

Department of Biochemistry Periyar University, Salem, Tamil Nadu, INDIA.

Abstract:

Aim: The study was designed to evaluate the antioxidant potential of eriodictyol on lipid peroxidation caused due to isoproterenol induced myocardial infarction in albino male wistar rats. Methods: Myocardial Infarction was induced by subcutaneous injection of isoproterenol, 85 mg/Kg body weight after a pretreatment period of 45 days with eriodictyol in various doses 50 mg, 100 mg and 200 mg per Kg body weight through intragastric intubation. The standard drug metoprolol succinate was administered orally at a dose of 2.5 mg per Kg body weight for 45 days followed by ISO induced myocardial infarction. Results: The study showed significant increase in the levels of thiobarbituric acid reactive substances, lipid hydroperoxides and conjugated dienes both in plasma and heart tissue with considerable decrease in the levels of enzymatic and non-enzymatic antioxidants in ISO induced myocardial infracted rats. The oral administration of eriodictyol showed significant decrease in lipid peroxidation products and with significant increase in the levels of antioxidants. The cardio protective role of eriodictyol was further assessed by histopathological studies. Conclusion: The results indicate that the oral administration of metoprolol succinate also modulates the lipid peroxidation and the antioxidant status in the ISO induced myocardial infracted rats.

Key words: Myocardial infarction (MI), Isoproterenol (ISO), Eriodictyol (E), Lipid peroxidation, Antioxidants, Acute Myocardial Infarction (AMI).

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs