Home | Articles
Published on:June 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(2s):s110-s114
Original Article | doi:10.5530/ijper.51.2s.56

Protective Effect of Aerva jevanica Against Ethanol Induced Hepatic Stress in Rats: A Randomized Control Report


Authors and affiliation (s):

Rahmat Ali Khan

Department of Biotechnology University of Science and Technology Bannu, KPK, PAKISTAN.

Abstract:

Background: Aerva jevanica (AJME) possess antioxidant activity and hepatoprotective effects, and traditionally in Pakistan for liver diseases. Methods: 24 male albino rats were divided into five groups of 4 chicks of each, having free access to food and water. Group I (control) while group II, III and IV were treated with ethanol 24 hrs for 2 weeks. Rats group II received only ethanol group III received silymarin at a dose of 50 mg/kg while group IV was given AJME (200 mg/kg). The activities of alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and were determined in serum. Catalase (CAT), peroxidase (POD), glutathione-S transferase (GST), glutathione peroxidase (GSH-Px), glutathione reductase (GSR) activity was measured in liver homogenates. Thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) concentration were also evaluated in liver homogenates. Results: Hepatotoxicity induced with ethanol was evidenced by significant increase in lipid peroxidation (TBARS) and serum, ALT, ALP, LDH. Level of GSH determined in liver was significantly reduced, as were the activities of antioxidant enzymes; CAT, POD, GSH-Px, GSR, GST treated with ethanol. AJME (200 mg/kg bw) and silymarin (50 mg/kg bw) co-treatment prevented all the changes observed with ethanol-treated rats. Conclusion: The results of present work indicate that AJME has a significant protective effect against ethanol induced hepatotoxicity in chicks, which may be due to their antioxidant potential.

Key words: Aerva Jevanica, Ethanol, Liver, Antioxidant Enzymes, Lipid Peroxidation.

 

Articles in PDF, ePUB and Full text are attached to this page. In order to download, print or access these formats you must be logged in.
CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
4 + 1 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.




 

User login

CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
2 + 9 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

DOI HISTORY

IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs