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Published on:March 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(3):480-489
Original Article | doi:10.5530/ijper.51.3.76

In vitro Antimicrobial Investigations of Newly Synthesized Transitional Bivalent Metal Complexes Derived from 8-Hydroxyquinoline


Authors and affiliation (s):

Sahoo Jyotirmaya1*, Sarangi Priyambada Kshiroda Nandini2, Paidesetty Sudhir Kumar3

1Department of Pharmaceutics, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, INDIA.

2Departmentof Pharmaceutical Chemistry, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, INDIA.

3Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar, INDIA.

Abstract:

Introduction: Novel Cu(II), Co(II) and Ni(II) complexes of 8-hydroxyquinolineazo analogues are synthesized from 5-((3-nitrophenyl)diazenyl) quinolin-8-ol (4a) and 5-((4-bromo-3- methylphenyl) diazenyl) quinolin-8-ol (4b). Methods: The structural environment and elemental composition of the synthesized metal complexes are confirmed by FT/IR, 1H NMR and CHNS/O elemental analyzer. The λ max and molecular mass are determined with the help of UV-visible and LC-MS spectrometer. Results: The magnetic susceptibility study suggested that the synthesized complexes are proposed with tetrahedral geometry. Among the six complexes, the bis bis 8, 8′ [5-((3-nitrophenyl) diazenyl) quinolinium] copper (4aLig2Cu) and bis 8, 8′ [5-((4-bromo-3-methylphenyl) diazenyl) quinolinium] copper (4bLig2Cu) showed significant antimicrobial activity. Conclusion: It was found that the metal complexes showed enhanced antimicrobial activity in comparison to their corresponding ligands.

Key words: Spectroscopic, Magnetic susceptibility, Antimicrobial, 8-Hydroxy quiniline, Antibiogram

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