Home | Articles
Published on:March 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(2):260-269
Original Article | doi:10.5530/ijper.51.2.31

Synthesis and Evaluation of Anticancer Activity of 1, 3, 4-Oxadiazole Derivatives against Ehrlich Ascites Carcinoma Bearing Mice and Their Correlation with Histopathology of Liver


Authors and affiliation (s):

Partha Pratim Roy1, Shalini Bajaj1, Tapan Kumar Maity2, Jagadish Singh1*

1Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Koni, Bilaspur, Chhattisgarh, INDIA.

2Department Of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, INDIA.

Abstract:

A series of 2, 5-disubstituted 1, 3, 4-Oxadiazole derivatives (4A-4G) have been synthesized with the help of different aromatic benzaldehyde and final compounds were characterized by FT-IR, 1H NMR and Mass spectroscopy. The anticancer study was investigated against Ehrlich Ascites Carcinoma (EAC) bearing albino mice. The synthesized (4A-4G) compounds were administered intraperitoneally at dose of 20-25 mg/kg; body weight per day for 7 days after 24 hour of tumor inoculation in mice. The standard compound used was 5-FU (20 mg/kg; body, weight). Synthesized compounds (4A-4G) remarkably decreased the body weight, tumor volume, packed cell volume, viable cell count and increased in tumor weight (%) inhibition, tumor cells (%) inhibition, the life span, nonviable cell count of EAC tumor bearing mice when compared with the control group. The liver section of EAC treated control group (II) was compared with the drug treated groups (III-X). The histopathological observations of test groups suggested that normal architecture of liver nucleus, parenchyma, and hepatic cells were regenerated, which was damaged in EAC control group. All the synthesized compounds (4A-4G) showed significant anticancer activity in EAC bearing mice which encourages us to develop/improve similar other compounds and test them for their anticancer activity.

Key word: Synthesis, 1, 3, 4 oxadiazole, EAC cell, Anticancer activity, FT-IR, NMR.

 

Articles in PDF, ePUB and Full text are attached to this page. In order to download, print or access these formats you must be logged in.
CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
14 + 2 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.




 

User login

CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
8 + 9 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

DOI HISTORY

IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs