Comparative Pharmacokinetic Study and Quantification of Ibuprofen released from Interpenetrating polymer Network Beads of Sodium Carboxymethyl Xanthan and Sodium Alginate

Abstract:

Aim: The purpose of this study was to determine the pharmacokinetic parameters of ibuprofen (IBP) in rabbits following administration of the drug-loaded interpenetrating network (IPN) beads and to compare the bioavailability of the drug from IPN beads with that from pure IBP and IBP Suspension. Materials and Methods: IPN beads, sodium carboxymethyl xanthan and sodium alginate was prepared by inotropic gelation process using AlCl₃ as a cross linking agent. The plasma drug concentration was determined by High Performance Liquid Chromatographic method according to validation guidelines 2001. The chromatographic separation was carried out in WATERX BDS, C₁₈ column with UV detection at 223 nm. Result: Though the maximum plasma concentration (C_max (32.11 ± 2.03)) obtained from pure IBP (control) was higher than that of IBP suspension (reference (C_max 30.05 ± 1.93)) and the time required to reach C_max (T_max) was less in the control (1.41 ± 0.37) than that of the reference product, the C_max was significantly less and T_max (2.91 ± 0.5) was higher from the drug loaded IPN beads than those from the both control and reference. Conclusions: Moreover, the relative bioavailability of the drug from the IPN beads was higher from the both control and reference products. This study revealed that IPN beads could be a suitable dosage form for IBP to achieve a sustained drug release.

Key words: IPN, Pharmacokinetic, Relative bioavailability, HPLC, Ibuprofen.