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Published on:August 2016
Indian Journal of Pharmaceutical Education and Research, 2016; 50(3):435-441
Original Article | doi:10.5530/ijper.50.3.17

Neuroprotective Activity of Garcinia pedunculata Roxb ex Buch Ham Fruit Extract Against Aluminium Chloride Induced Neurotoxicity in Mice.


Authors and affiliation (s):

Ravi Mundugaru1, Sunil Kumar Koppala Narayana2, Shrinidhi R Ballal3, Jacob Thomas4*, Rajakrishnan R4

1Department of Pharmacology and Toxicology, SDM Centre for Research in Ayurveda and Allied Sciences, Kuthpady, UDUPI.

2Department of Pharmacognosy, SDM Centre for Research in Ayurveda and Allied Sciences, Kuthpady, UDUPI.

3Department of Agada Tantra, SDM College of Ayurveda, Kuthpady, UDUPI.

4Department of Botany & Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, SAUDI ARABIA.

Abstract:

Aluminium chloride (AlCl3) is a known potent environmental neurotoxin causing progressive neurodegenerative changes in brain. The present study was aimed to evaluate the neuroprotective activity of aqueous extract of fruit rind of Garcinia pedunculata on chronic exposure of aluminium chloride induced neurotoxicity in Swiss albino mice. Albino mice were categorized into four different groups; Group 1–served as vehicle control, Group 2 mice were administered with AlCl3 40 mg/kg body weight i.p. for 45 consecutive days. Groups 3 & 4 mice were administered with AlCl3 40 mg/kg body weight i.p. for 45 consecutive days along with aqueous extract of fruits of G. pedunculata 200 & 400 mg/kg body weight. Chronic administration of AlCl3 developed behavioral deficits, triggered lipid peroxidation and AChE activity and reduced levels of catalase, glutathione peroxidase and histological aberrations. Co administration of aqueous extract of G. pedunculata has attenuated the AlCl3 induced alteration in the behavioral, lipid peroxidation, catalase, glutathione peroxidase, AChE and histological changes of brain tissue. Thus the results of the present study have demonstrated the protective role of aqueous extract of fruit rind of G. pedunculata against AlCl3 induced neurotoxicity.

Key words: Acetylcholine esterase, Aluminium chloride, Garcinia pedunculata, Lipid peroxidation, Neurotoxicity.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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