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Published on:11th Feb, 2015
Indian Journal of Pharmaceutical Research and Education, 2011; 45(4):353-359
Pharmaceutical Education | doi:Nill

Study of the Influence of Primary Packaging on Photostability of Tablets Containing Carvedilol


Authors and affiliation (s):

Ivan Savic*1 , Valentina Marinkovic2, Ivana Savic2 and Predrag Sibinovic3

1Faculty of Technology, University of Nis, Bulevar oslobodjenja 124, Leskovac, Serbia,

2Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, Belgrade, Serbia,

3Pharmaceutical and Chemical Industry - Zdravlje Actavis, Quality Control Department, Leskovac, Serbia.

Abstract:

The aim of this work was to select an appropriate primary packaging and analysis of its influence on stability, of tablets containing Carvedilol (Karvileks, Zdravlje-Actavis, Serbia). The influence of different primary packaging materials and doses radiation was investigated. Karvileks tablets were put in an opaque plastic container, red and white blister packs, composed of polyvinyl chloride and aluminum foil (PVC/Al). After radiation, the content was estimated using a validated HPLC method. Tablets, packaged in different primary packaging materials, were exposed at different doses of UV and VIS radiation. In case of blister packs, the content of active substance was lower than 85% compared with an initial content. Tablets packaged in the opaque plastic containers, the content of carvedilol was not lower than 90%, after radiation. The study showed that the opaque plastic containers provide better photo protection than red and white blister packs for solid oral dosage forms of Karvileks.

Keywords: Karvileks, photostability, HPLC, packaging, tablets.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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