Natural products including plants offer large structural diversity of chemicals to be used as various class of pharmacological disorders and modern techniques for separation, structure elucidation, screening and combinatorial synthesis have led to revitalization of plant products as sources of new drugs. Synergistic interactions are of vital importance in phytomedicines. Eventhough several difficulties are faced, isolating the single active compound from the phytomedicine is always targeted. But the efficacy of the whole herb may lie on the low doses of the active constituents present in an herbal product altogether. Until recently there has been little clinical evidences demonstrated which showed that very low dose of the active constituents exert any therapeutically relevant effect. Most of the effective phytomedicines sold on the market are prepared traditionally which are available as whole extracts or individual herb. The alternative medicine practitioners have always believed that synergistic interactions between the components of individual or mixtures of herbs are a vital part of their therapeutic efficacy. In the absence of clinical proof this has led skeptics to dismiss these medicines as placebos, and it is compounded by the fact that there may be result in a measurable efficacy only after continuous administration, which might be due to a cumulative effect.