Formulation and Evaluation of Topical Liposomal Gel for Fluconazole

Abstract:

Liposomal carriers, well known for their potential in topical drug delivery have been choosen to help fluconazole molecules in the skin layers. In the present work statistical study for the formulation of liposomes for topical delivery of fluconazole using the factorial design approach was undertaken. Amount of phospholipid (PL 90H) and cholesterol (CH) were taken at three different levels and liposomes were prepared using film hydration technique. Gels containing liposomes (optimized batch) were prepared in Carbopol® 934 NF and were characterized for rheology, spreadability, permeation and drug deposition in the rat skin. Results of regression analysis revealed that vesicle size and entrapment efficiency were dependant on the cholesterol and lipid concentration. Rheological studies of all liposomal gels prepared with 1%, 1.5%, and 2% w/w carbopol gave a clear idea of concentration of carbopol required. Liposomal dispersion and gels were found to increase the skin permeation and deposition compared to control and marketed gel. Liposome dispersion and gel formulation were found to be stable for 60 days.

Key Words: Factorial design; fluconazole; liposomes; gels; topical