In vivo Methods for Evaluation of Drugs for the Treatment of Gastrointestinal Motility Disorders

Abstract:

The gastrointestinal tract (GIT) performs multitude of essential functions after ingestion of food, finally leading to absorption of nutrients. These functions are directly influenced by the motility patterns of the gut and any aberration in such patterns can disturb functionality of the GIT. The evaluation of gastrointestinal (GI) motility with suitable a probe is helpful in determining the therapeutic potential of investigational drugs in various motility disorders. The clinical conditions of motility disorders such as achalasia, gastric stasis, outlet obstruction, etc., deserve treatment with safer drugs. In vivo methods exhibit true effects of investigational drugs in biological milieu. This paper describes various in vivo methods of assessment of GI motility from stomach to colon. Among all the methods the visible marker methods are known to be simple and inexpensive