Cobalt and Iron-based Heteroleptic Complexes of Imidazole: Synthesis, Antibacterial and Hemolytic Potential

Abstract:

Transition metal complexes can deliver exciting properties in the development of metalbased drug system. The aim of current study is to synthesis of metal complexes and to evaluate their biological properties such as antibacterial and hemolytic activity to know their biological importance. Five cobalt and iron-based complexes (1-5), [CoII(imiH)(benz) (N3)] (1) [FeII(imiH)(piv)(N3)] (2), [FeII(imiH)(benz)(N3)] (3), [FeII(imiH)(N3) 2] (4), [FeII(imiH) (piv)2] (5), (where imiH = imidazole, piv = pivalic acid, N3- = azide, benz = benzoic acid) were produced by of the reacting of respective metal salts with selective ligands. These complexes were characterized through FTIR and elemental analyses. Compounds (1-5) were tested for their antibacterial biofilm inhibition and hemolytic studies. Complexes of 3 (85.42%) and 2 (69.58%) have promising inhibition for S. aureus whereas 5 (70.48%) and 2 (62.94%) also exhibit significant inhibition against E. coli. The hemolytic study of these metal complexes indicates the cytotoxicity against bovine erythrocytes. The current study will be useful for the development metallodrugs in future.

Keywords: Transition metal complexes, Carboxylates, Imidazole, Sodium azide, Biological studies.