In the present study, the petroleum ether extract of Dregea volubilis (PEDV) was evaluated for its protective effect on paracetamol-induced liver damage in Wistar rats. Serum biochemical parameters viz. serum glutamine oxaloacetate transaminase (SGOT), serum glutamine pyruvate transaminase (SGPT), serum alkaline phosphatase (SALP), total protein, bilirubin, cholesterol, triglyceroides; and liver biochemical parameters such as lipid peroxidation, reduced glutathione (GSH) content and catalase (CAT) activity were estimated. Overall biochemical observations indicated that PEDV exerted remarkable hepatoprotective efficacy against paracetamol-induced hepatic damage in rats that is may be due to its augmenting endogenous antioxidant mechanisms.
Keywords: Dregea volubilis, Hepatoprotective, lipid peroxidation, glutathione, silymarin