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Published on:1 January, 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(1):59-65
Research Article | doi:NILL

Genetic Algorithms-Based Approach for Wavelength Selection in Spectrophotometric Determination of Paracetamol and Chlorzoxazone in Tablet Preparation by Partial Least-Squares

Authors and affiliation (s):

Lawan Sratthaphut1,* and Chutima Phechkrajang2

1Department of Health-Related Informatics, Faculty of Pharmacy, Silpakorn University, 6 Rachamankhanai Rd., Sanam Chandra Palace Campus, Nakhon Pathom 73000, Thailand

2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayudhaya Rd., Rajathevee, Bangkok 10400, Thailand


This study illustrated the genetic algorithms (GA) is useful tool in wavelength selection for the simultaneous spectrophotometric determination of paracetamol (PAR) and chlorzoxazone (CZX) in a multicomponent pharmaceutical dosage form by partial least-squares calibration procedure. Artificial, a training set of the mixtures of PAR and CZX corresponding to central composite design was built to be used as calibration set for PLS and GA-PLS. Synthetic mixtures were used to verify the models. Reasonably good recoveries were obtained and it leads to 32% improvement of predictive ability for PAR and 35% for CZX, respectively. A commercial sample containing two drugs was assayed, and there was statistically no significant difference (P < 0.05) between the results with GA-PLS method and those obtain with the official method. The proposed method has been proved to be beneficial for the determination of both drugs in pharmaceutical tablets without prior extraction.

Keywords : Genetic algorithms, Partial least-squares, Paracetamol, Chlorzoxazone



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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