Home | Articles
Published on:March 2021
Indian Journal of Pharmaceutical Education and Research, 2021; 55(1s):s164-s175
Original Article | doi:10.5530/ijper.55.1s.47

Development of Budesonide Oral Colon Specific Drug Delivery System using Interpolymer Complexation Method


Authors and affiliation (s):

Patil Ramgonda, Rajashree Shashidhar Masareddy*, Archana Patil, Uday Bolmal

Department of Pharmaceutics, JNMC Campus, KLE Academy of Higher Education and Research, KLE College of Pharmacy, Belagavi, Karnataka, INDIA.

Abstract:

Background: Oral bioavailability of Budesonide is 10% due to its extensive first pass metabolism, its high volume of distribution and 85-90% of protein binding. Protection of drug release in stomach and targeting drug to colon which is an absorption site of drug is an attempt to improve therapeutic efficacy. The objective of this study was to develop interpolymer complex microspheres of Budesonide for oral colon specific drug delivery. Methods: Emulsion solvent evaporation method was used in the preparation of microspheres. Microspheres prepared at different polymer ratio and surfactant concentration were analysed for its mean particle size, surface morphology, flow property, drug release, % encapsulation efficiency. Results: Microspheres prepared with 3:5 polymer ratios F4 was optimized with respect to its % EE, in vitro drug release and percentage yield. Drug release from formulated tablets containing microspheres of 3:5 polymer ratios showed an extended release up to 12 h in pH buffer 7.4. Interpolymer complexation was confirmed by FT-IR studies, compatibility of drug with excipients by DSC indicated no significant changes with drug. SEM studies revealed formation of round microspheres with pervious and uneven surface. In vitro release data from microspheres was analysed by kinetic model fitting for mechanism of drug release. Microspheres showed 5-10% of drug release in pH 1.2 which was further prevented by formulating coated tablets of microspheres using cellulose acetate phthalate. Conclusion: Targeted colon specific drug delivery of Budenoside with extended release up to 12 h was successfully achieved by formulation of tablets containing microspheres prepared by interpolymer complexation technique.

Key words: Budesonide, Colon Specific Delivery, Interpolymer Complexation, Microspheres, Cellulose Acetate phthalate.

 




 

Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

DOI HISTORY

IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs