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Published on:February 2021
Indian Journal of Pharmaceutical Education and Research, 2021; 55(2):xx-xx
Original Article | doi:10.5530/ijper.55.1s.x

Kalanchoe daigremontiana: Functional Properties and Histopathological Effects on Wistar Rats under Hyperglycemia-inducing Diet


Authors and affiliation (s):

Alfredo Madariaga-Navarrete1, Eliazar Aquino-Torres1, Raquel Cariño-Cortéz2, Roberto Villagómez-Ibarra3, Juan Ocampo-López4, Ashutosh Sharma5, Alma Delia Hernández-Fuentes6,*

1Área Académica de Ciencias Agrícolas y Forestales, Instituto de Ciencias Agropecuarias, Universidad Autónoma del Estado de Hidalgo. Tulancingo, Hidalgo, MEXICO.

2Instituto de Ciencias de la Salud. Universidad Autónoma del Estado de Hidalgo. Pachuca, Hidalgo, MEXICO.

3Área Académica de Química, Instituto de Ciencias Básicas e Ingeniería, Universidad Autónoma del Estado de Hidalgo. Pachuca, Hidalgo, MEXICO.

4Área Académica de Medicina Veterinaria, Instituto de Ciencias Agropecuarias, Universidad Autónoma del Estado de Hidalgo. Tulancingo, Hidalgo, MEXICO.

5Tecnologico de Monterrey, School of Engineering and Sciences, Epigmenio Gonzalez San Pablo, Querétaro. Qro, MEXICO.

6Área Académica de Ingeniería Agroindustrial, Instituto de Ciencias Agropecuarias, Universidad Autónoma del Estado de Hidalgo. Avenida Universidad Km, Exhacienda Aquetzalpa Tulancingo, Hidalgo, MEXICO.

Abstract:

Introduction: Diabetes is a worldwide pandemic disease with an expensive way of control. Locals around the world have been used botanical extracts to reduce the effects of this deadly disease to improve the quality of life of the patients. Objectives: To evaluate the effects of crude extracts of the ethnobotanical species K. daigremontiana on a hyperglycemia rat model to support its antidiabetic use in traditional medicine. Materials and Methods: Crude leaves extract were daily administered per os to Wistar rats for six months. Hyperglycemic induction model was rich-sucrose diets. Six animals per group were used: i) standard diet, ii) sucrose-rich diet, iii) sucrose-rich diet + extract (1 ml), iv) sucrose-rich diet + extract (2 ml) and v) standard diet + extract (2 ml). All animals were sacrificed and the liver prepared for histopathological analysis. Powdered leaves were functionally characterized and analyzed by Fourier Transform Infrared (FTIR) spectroscopy. Results: Treatment with 2 ml of the crude extract caused the least tissue damage, compared to the control. A high antioxidant activity (DPPH: 111.14 μM Trolox equivalents g-1 dry weight (DW); ABTS: 223.90 μM Trolox equivalents g-1 DW) was observed. A content of 0.54 mg ascorbic acid g-1 DW, total phenol content of 17.45 mg gallic acid g-1 DW and flavonoid content of 2.3 mg equivalent quercetin g-1 DW were determined. No conclusive evidence on the molecules present in the extract was obtained by FTIR spectroscopy. Conclusion: The use of dosages of 2 ml of crude extract of Kalanchoe daigremontiana reduces liver damage under high sucrose conditions.

Key words: Traditional medicine, Anti-hyperglycemic, Diabetes Sucrose-rich diet, Kalanchoe daigremontiana, Phytotherapy.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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