Home | Articles
Published on:1 January, 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(1):4-8
Research Article | doi:NILL

Antihepatotoxic Activities of Ci Compound: ß Sitosterol Isolated from Fruits and Leaves of Coccinia indica

Authors and affiliation (s):

Shivaji P Gawade*,1 and Chandrashekar Rao M.V2

1Satara college of Pharmacy, Plot 1539, New additional MIDC, Degaon, Satara-415004, M.S., India

2Department of Pharmacology, Al-Ameen College of Pharmacy, Near Lalbagh Main Gate, Hosur Road, Bangalore-560027, K.S., India


Ethanolic extract of fruit and leaves of Coccinia indica revealed the presence of saponins. The purified fraction Ci from ethanolic extract by gradient silica gel column chromatography in the dose 25 mg/kg (Ci-1) and 50 mg/kg (Ci-2) (p.o.) showed significant dose dependent reduction in SGPT,SGOT, bilirubin, total protein, liver weight and lipid peroxide levels with reference to the standard, silymarin (25 mg/kg, p.o).The Ci compound also revealed significant dose dependent reduction in the hepatic antioxidant enzyme activities such as super oxide dismutase, 1 12 glutathione, catalase, and peroxidase. The structural characterization of Ci compound by microanalysis, UV, IR, 1H NMR, 13C NMR spectroscopy and Mass spectrometry revealed structure with molecular formula C29H50 O ( beta sitosterol ). Hepatoprotective potential of Ci 29 50 compound,  beta sitosterol was inferred from it's antihepatotoxic activities on serum transaminases and hepatic antioxidant enzymes in CCl4 intoxicated rats.



Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).


Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

User login

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs