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Published on:1 January, 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(1):9-16
Research Article | doi:NILL

Antidiabetic Effect of Flower Extract of Antigonon leptopus Hook & Arn in Alloxan-induced Diabetic Rats


Authors and affiliation (s):

Sujatha S, Swaroopa Rani V*and Ravikumar B

1Department of Pharmacognosy, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009, Andhra Pradesh, India

Abstract:

The antidiabetic effect of methanolic extract of flowers of Antigonon leptopus (MFAL) was evaluated at three different doses i.e. 100, 200 and 400 mg/kg, p.o. in normal, glucose fed and alloxan-induced diabetic rats. The antihyperglycemic effect of MFAL at 200 mg/kg b.w. was relatively better than that of the other two test doses (100 and 400 mg/kg, b.w.), with respective to the percent reduction of blood glucose level during the entire period of study. In sub acute study (21 days), the antihyperglycemic effect of MFAL at 200 mg/kg b.w. was supported by the reversal of changes occurred in other parameters such as body weight, serum insulin, aspartate transaminase (AST), alanine transaminase (ALT), serum triglycerides, serum cholesterol and serum total proteins, which are implicated in diabetes. Hypoglycemic and antidiabetic effects of the MFAL were found to be well comparable with glibenclamide (10 mg/kg, b.w, p.o.), a reference drug used in type 2 diabetes therapy.

Keywords: Antigonon leptopus, Alloxan, Antidiabetic effect, Glibenclamide.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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