Cucurbita pepo and Cucurbitacin in the Management of Anti-proliferation by JAK/STAT Pathway

Abstract:

Pumpkin (Cucurbita pepo) is capaciously recycled similar to food and in folk medicine throughout the world. It accords to genus Cucurbita (C_CT) under family Cucurbitaceae. There are a plenty of important medicinal phyto-constituents belonging to cucurbitoside like triterpenoids, C^AR_T and C_CT glycosides. A survey of the literature demonstrates that C. pepo, has the capacity to improve prostatic hyperplasia, urinary dysfunction and cytotoxic properties. Many pharmacological revisions have established its role in hepatoprotection, inhibition of P_r^st gland cancer (C_NCR), anti (Aⁿ_t) oxidant effects, inhibition of L_u^G, B_R^st and triple-negative B_R^st C_NCR by blocking JAK/STAT signaling (S_gls) pathway (P_tw). It has also Aⁿ_t microbial, Aⁿ_t -inflammatory, Aⁿ_t -diabetic and Aⁿ_t ulcer activities by supporting its traditional claims. Establishment of C. pepo and cucurbitacin (CCBT) in the management of Aⁿ_t -proliferation by JAK/STAT P_tw. Data towards writing this review are generated through exploration of different websites like MEDLINE (PubMed), Google Scholar, Science Direct, Scopus, Cochrane, SID and Magiran databases. We have selected 2016- 2018 duration for the same purpose. We have found 88 papers related to this topic. CCBT is found to arrest unlimited cell (CEL) division and respective apoptosis (A_ppt) in vitro and in vivo C_NCR models. A plenty of molecular design targeting CCBT have been invented, such as fibrous-actin, S_gls transducer and activator of transcription (STAT), cyclooxygenase-2, etc. This review is minded at CCBT from C. pepo which dwindle the proliferation of human C_NCR CEL through the JAK/STAT P_tw.

Key words: Anticancer activity, Cucurbita pepo, Cucurbitaceae family, JAK/STAT pathway, Cucurbitacin, Cyclooxygenase-2.