Home | Articles
Published on:Apr 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(2):137-144
Original Article | doi:NILL

Formulation Design and Characterization of Kollidon SR Based Trimetazidine Dihydrochloride Matrix Tablets

Authors and affiliation (s):

Mohammad Salim Hossain*, Sujan Banik and Mohammad Safiqul Islam

1Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3802, Bangladesh


The purpose of the present study was to formulate sustained release Trimetazidine Dihydrochloride matrix tablets by using Kollidon SR as rate controlling polymer. Each of the formulated tablet contains 35 mg of Trimetazidine Dihydrochloride. The tablets were prepared by direct compression method. The granules were evaluated for angle of repose, bulk density, tapped density and compressibility index. The formulated tablets were evaluated for weight variation, thickness, diameter, hardness, friability and drug content and also in-vitro dissolution studies. Drug content in formulation was determined by UV method. The granules showed satisfactory flow properties. All the tablet formulations showed acceptable pharmacotechnical properties and complied for tested parameters. The in-vitro release study of matrix tablets were carried out in phosphate buffer with pH 7.4 for 7 hours. The drug release from each formulation was analyzed by using release kinetic theories. The results of dissolution studies indicated that all the formulations exhibited drug release pattern very close to theoretical release profile. Applying kinetic equation models, the mechanism of release of the drug from all the formulations were found to be followed Higuchi model, as the plots showed high linearity, with correlation coefficient (r2) value of 0.93 or more. The 'n' value lies between 0.45 <n<0.89 (Korsmeyer-Peppas model) demonstrating that the mechanism controlling the drug release was the anomalous non-Fickian or anomalous release. The mean dissolution time (MDT) was calculated for all the formulations and the highest MDT value was obtained with formulation 1. Therefore, the results generated in this study showed that the formulated sustained release matrix tablets deliver the drug through a combination of both diffusion and erosion controlled mechanism.
Keywords: Trimetazidine Dihydrochloride, Kollidon SR, Matrix Tablet



Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).


Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

User login

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs