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Published on:March 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(2):357-366
Original Article | doi:10.5530/ijper.54.2.41

Cyclosporine A Loaded Nanoemulsions using Bio-oil Fractions of Sesame Oil


Authors and affiliation (s):

Samir Bhargava1,2,*, NV Satheesh Madhav1

1DIT-Faculty of Pharmacy, DIT University, Dehradun, Uttarakhand, INDIA.

2Faculty of Pharmacy, Uttarakhand Technical University, Dehradun, Uttarakhand, INDIA.

Abstract:

Title: Cyclosporine A loaded Nanoemulsions using Bio-oil Fractions of Sesame Oil. Aim: Nanoemulsions formulation development is an upcoming approach to deliver peptides. The approach reduces challenges during peptide delivery by many folds. Nanoemulsions contains drugs encapsulated or solubilized in an oily phase, with water as continuous phase. In our research, nanoemulsion have been developed for Cyclosporine a using fractions of Sesame oil as encapsulating agent. Methods: The comparison between oil fractions (SOC; SOAM) and Sesame oil have been well proved through Spectral studies like FT-IR, GC-MS and rheology studies. Nanoemulsions have been developed using a modified solvent-evaporation method. FT-IR of oil fraction also shows absence of peaks showing peptide fragments, indicating its encapsulation inside oil fraction. Conclusion: The zeta potential of our selected formulation FSC2 among FSC1-FSC12 has been found to be -15 mV, while its polydispersity is 0.325. The in vitro studies clearly reveals first order release mechanism as best fit model for selected formulation. The r2 for selected formulation has been identified to be 0.99. The t80 of FSC2 has been found to be 6.5 Hrs. The TEM Studies of formulation reveal spherical appearance of particles with average particle size between 50-220 nm.

Key words: Cyclosporine A, Nanoemulsions, Sesame oil, Biolipid, GCMS, IR.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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