Home | Articles
Published on:Apr 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(2):192-196
Original Article | doi:NILL

Formulation and In-vitro Evaluation of Zidovudine-Lamivudine Nanoparticles

Authors and affiliation (s):

Sankar V*, Madhura Keerthi L and Nilaykumar Parmar

Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore, Tamil Nadu, India - 641004


Human Immunodeficiency Virus infection and Acquired Immune Deficiency Syndrome commonly referred to as HIV/AIDS which have emerged as being the most serious and challenging public health problems in the world. Zidovudine-Lamivudine nanoparticles were prepared by emulsion polymerization in a continuous aqueous phase with different polymers poly(lactic-co-glycolic acid) PLGA (50:50), Poly(lactic acid) PLA, Poly (methyl methacrylate) PMMA, Methylmethacrylate-Sulfopropylmethacrylate (MMA-SPM). The particle size and the surface morphology results revealed that PLGA nanoparticles (NPs) were smooth spherical with a size ranging from 58-224 nm. The drug content in lyophilized PLGA NPs was found to be 51.67% (Zidovudine) 58.33% (Lamivudine) and no drug loss was found after storage for 1 month at room temperature. In vitro release studies revealed that the rate of drug release from PLGA NPs was 95.38% in 10 h with zidovudine, and 97.37% in 10 h with lamivudine which was slower when compared to MMA-SPM, PLA and PMMA NPs. The rate of drug release from MMA-SPM NPs was 64.33% in 10 h with zidovudine and 95.43% in 10 h with lamivudine. Acute toxicity studies in mice revealed that the dose administered does not induce mortality in test animal. Keywords: HIV, Nanoparticles, Emulsion Polymerization method, In vitro release, Stability study.



Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).


Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

User login

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs