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Published on:March 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(2):323-328
Original Article | doi:10.5530/ijper.54.2.37

Pro-Argin Technology Based Formulation of Eugenol Containing Toothpaste

Authors and affiliation (s):

Dhanashri Dhananjay Shete, Minakshi Arun Patmas*, Shriniwas Pramod Patil

Department of Pharmacognosy, SCES’s Indira College of Pharmacy, Tathawade, Pune, Maharashtra, INDIA.


Introduction: Formation of cavities and hyper sensitivity are few dental problems, manifested by dental pain. Since long back, volatile oil present in clove buds (Myrtaceae) have been used as dental analgesic. Various toothpastes containing clove oil are marketed. Eugenol is chemically, terpenoids, active principle present in clove oil. It has several pharmacological potentials. Pro-argin technology is novel approach for formulation of toothpaste with arginine (8%) and calcium carbonate. Aim: This research was aimed towards formulation of toothpaste containing eugenol by Pro-argin technology and its evaluation. Materials and Methods: Toothpaste containing eugenol was formulated with arginine (8%) and calcium carbonate by simple trituration. Formulation was then evaluated for various parameters like pH, spreadability, foaming ability, content determination and also analysed for texture. Results and Discussion: On formulation, brownish, aromatic fragrant toothpaste was obtained with acceptable pH, spreadability and foaming ability. About 92.48% of eugenol content of added quantity was determined. Conclusion: Eugenol can successfully be formulated in toothpaste by Pro-Argin approach. More than 90% content determination would facilitate maximum release of added eugenol.

Key words: Clove oil, Eugenol, Pro-argin technology, Toothpaste, Texture analysis.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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