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Published on:November 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(4s):s650-s654
Original Article | doi:10.5530/ijper.53.4s.161

Potential Effect of Steroidal Alkaloids from Sarcococca saligna against Leishmania tropica


Authors and affiliation (s):

Naeem Ullah Jan1,*, Bashir Ahmad2, Muhammad Kifayatullah1, Haroon Rahim1, Fazli Amin1

1Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, PAKISTAN.

2Centre of Biotechnology and Microbiology, University of Peshawar, Peshawar, PAKISTAN.

Abstract:

Background and Objectives: Sarcococca species have a rich source of steroidal alkaloids that possess different biological and pharmacological activities. Hence, present research was design to isolate the steroidal alkaloid from Sarcococca saligna and to evaluate it for in-vitro antileishmanial activity. Materials and Methods: Compound Holaphylline and Saracodine were isolated through column chromatography followed by spectroscopic techniques for elucidation and were assayed against promastigotes of Leishmania tropica. Results: Saracodine compound eliminates 71.12%, 63.9%, 54.18% and 38.88% of the promastigotes at concentration 100 μM; 75 μM, 50 μM and (25 μM). While, the elimination of promastigotes with compound holaphylline were 82.5%, 76.68%, 65%, 47.22% respectively as compared to untreated group. Conclusion: In present study, compound Holaphylline and Saracodine exhibited inhibition against the promastigotes and justified the claimed medicinal importance of Sarcococca saligna as a remedy for leishmaniasis especially against Leishmania tropica.

Key words: Sarcococca saligna, Holaphylline, Saracodine, Leishmania tropica, Promastigotes, Chloroform extract.

 

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IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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