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Published on:Apr 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(2):168-173
Original Article | doi:NILL

Bronchoprotective, Bronchodilatory and Anti-Inflammatory Activity of Ethanolic Extract from Woodfordia fruticosa (Kurz.) Flowers


Authors and affiliation (s):

M.H. Ghante*1(a), K.P. Bhusari1, N.J. Duragkar1, N.S. Jain2 and A.S. Warokar1

1Sharad Pawar College of Pharmacy, Wanadongari, Hingna Road, Nagpur-441 110 (M. S.), India. & (a)Nanded Pharmacy College, Shyam Nagar Nanded - 431605 (M.S)

2J. L. Chaturvedi College of Pharmacy, Electronic Zone, M. I. D. C. Hingna Road, Nagpur-440 016 (M. S.), India.

Abstract:

The present investigation was aimed to investigate the bronchoprotective, bronchodilatory and anti-inflammatory effect of ethanol extract of Woodfordia fruticosa dried flower (WF-EE). WF-EE exhibited significant and dose dependent bronchoprotective, bronchodilatory and antiinflammatory effect. WF-EE at 200 mg/kg prolonged the latent period and exhibited protection against experimental asthma induced by the combination of histamine and acetylcholine aerosol in guinea pigs. WF-EE (1 mg/ml) exhibited 100 % bronchodilation (complete bronchorelaxation) at concentrations 1.6 and 3.2 mg against acetylcholine and histamine induced contraction respectively. Administration of extract (100 or 200 mg/kg, p.o.) to rats showed significant inhibition of carrageenan as well as egg albumin induced paw edema. The antiinflammatory effect of extract at 200 mg/kg was comparable to standard drug indomethacin (10 mg/kg, p.o.). Moreover, WF-EE has not shown any toxicity symptoms and mortality up to 2000 mg/kg, p.o. in rats, when evaluated for the acute toxicity study of WF-EE as per OECD guidelines. These results suggest the anti-asthmatic (bronchoprotective as well as bronchodilatory) and anti-inflammatory potential of WF-EE along with safety margin for oral administration. Keywords: Woodfordia fruticosa, asthma, bronchodilation, guinea pig trachea, anti-inflammatory, carrageenan, egg-albumin.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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