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Published on:November 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(4s):s619-s623
Original Article | doi:10.5530/ijper.53.4s.157

Development of Non-invasive Electroencephalography Technique in Animal Model

Authors and affiliation (s):

Vasudeva Murthy Sindgi1,*, Mounika Basani1, Pragna Choudary1, Kashinath Molugu1, Ramesh Malothu2

1Jayamukhi College of Pharmacy, Narsampet, Warangal, Telangana, INDIA.

2School of Biotechnology IST, JNTUK – Kakinada, Andhra Pradesh, INDIA.


Aim: This paper describes about the new non-invasive method to measure brain waves from the scalp of the rats. The method allows to record good quality Electroencephalogram (EEG) from freely moving rats in the cage. Methods: This experiment targeting rodents used simple adhesive patch containing conductive gel placed on the scalp of the rats has a potential to measure the brain waves without any surgical intervention. Stable electrode gel shown to have good conductivity and strongly bonds to the skin of the animal and is well suited for recording from awaken and freely moving rats. We used two channel data acquisition system to convert analogue to digital signals of the brain waves. This study conducted to record the accurate electroencephalograph signals, a helpful tool for the translational research. The major advantages of the non-invasive EEG recording in contrast to the invasive method we presented here an efficacious, quick and efficient technique for the placement of the EEG leads in rats. Results: Quality EEG data obtained using two channel data acquisition system and is used for analysis. Reliable estimation of the electrical activity of the brain from conscious rat can be made. In conventional procedures electrodes are implanted in the skull with an additional stressful procedure. Conclusion: The results provided evidence that this method can be used as an alternative to the conventional recording of the electroencephalogram. This tool definitely a valuable tool in basic research, neurodegenerative and epilepsy research.

Key words: Electroencephalogram, Fast Fourier Transform, Stereotaxis equipment, Frequency bands, Conductive gel, Absolute Power.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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