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Published on:Jul 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(3):206-210
Original Article | doi:NILL

Synthesis and Pharmacological Evaluation of New 4-Aryl-3,4,5,6,7,8- hexahydroquinazolin-2(1H)-thiones


Authors and affiliation (s):

C.M Aslak, B. Jayalakshmi*, A.Balasubramaniam and N. Senthilkumar.
Department of pharmaceutical chemistry, JKK Munirajah Medical Research Foundation, College of Pharmacy, Komarapalayam - 638 183,Tamilnadu, India

Abstract:

New 4-aryl substituted quinazolin-2-thiones were synthesized and confirmed by spectral studies like IR and NMR. Then screened for antimicrobial, analgesic, anti-inflammatory and CNS depressant activities. All the derivatives were showing the pharmacological activity mainly due to the presence of basic nucleus, quinazolin-2-thione and was modified with various substituents at 4th position with different aryl substituents. Among all the substituents, the halogen substituted compounds are comparatively more active.

Keywords: Quinazolinones, cyclohexanone, chalcones, Aldol condensation, cylization.

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