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Published on:November 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(4s):s475-s480
Review Article | doi:10.5530/ijper.53.4s.141

Recent Advancements in Spectrophotometric pKa Determinations: A Review

Authors and affiliation (s):

Job Herman Berkhout1, Aswatha Ram HN2,*

1Faculty of Science, Radboud University, Nijmegen, NETHERLANDS.

2Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA.


The pKa value is a key feature in Absorption, Distribution, Metabolism and Excretion (ADME) of drugs, thus knowing this value is critical in drug development. In this review, pKa values determined in the past decade, using UV-Vis spectrometry, are discussed. To determine the pKa, four methods were applied; Henderson-Hasselbach, Albert-Serjeant, Bates-Schwarzenbach and Spectrometric titrations. This review will show the value of this aged but well-established technique in the past decade, due to its simplicity, accuracy, cost efficiency and reproducibility.

Key words: Albert-Serjeant, Bates-Schwarzenbach, Henderson-Hasselbach, pKa, Spectroscopy, Titrations.



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IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).


Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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