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Published on:November 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(4s):s684-s690
Original Article | doi:10.5530/ijper.53.4s.165

Analgesic and Anti-allodynic Effects of Two Flavonoids in Partial Sciatic Nerve Ligation in Rat Model

Authors and affiliation (s):

A.C. Rana*, Bhawna Gulliya, Swati Rana

Swati Rana Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana, INDIA.


Background: Flavonoids, also called as bioflavonoids, are secondary metabolites of plants. Flavonoids, curcumin and hesperidin, possess various pharmacological activities such as analgesic, anti-ulcer, anti-parkinson, anti-cancer, spasmolytic, anti-bacterial, anti-depressant, anti-hypertensive, anti-arthritic and anti-inflammatory. Aim: The current study investigated the analgesic and anti-allodynic effects of flavonoids (curcumin and hesperidin) and compared their effects with pregabalin against experimentally induced neuropathic pain in Swiss albino rats. Methods: Behavioral parameters were investigated in partial sciatic nerve ligation rat model. Surgery was performed by exposing and ligating the right sciatic nerve. Heat hyperalgesic and cold allodynic tests were assessed using Eddy’s hot plate and submerging rat’s right hind paw in ice cold water (4 ± 1oC), respectively on days 4,7,10,13,16,19 and 22. Surgery was considered as day 1. Flavonoids and pregabalin (10mg/kg, p.o.) were administered for fifteen days. Results: Partial sciatic nerve ligation of right sciatic nerve significantly induced thermal hyperalgesia and cold allodynia. Administration of hesperidin (100mg/kg, p.o.) and curcumin (100mg/ kg, p.o.) showed significant increase in paw withdrawal latency in both the behavioral tests. Results of behavioral tests have shown curcumin to be a little more effective than hesperidin in attenuating the neuropathic pain. Conclusion: It can be concluded that both hesperidin and curcumin attenuate the neuropathic pain induced by partial sciatic nerve ligation in rats. However, curcumin showed more significant results than hesperidin.

Key words: Flavonoids, Neuropathic pain, Analgesic, Anti-allodynic, Curcumin, Hesperidin, Partial Sciatic Nerve Ligation (PSNL), Hyperalgesic.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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